𝐀𝐝𝐯𝐢𝐜𝐞 𝐭𝐨 𝐚 𝐡𝐞𝐚𝐥𝐭𝐡 𝐨𝐮𝐭𝐜𝐨𝐦𝐞𝐬 𝐫𝐞𝐬𝐞𝐚𝐫𝐜𝐡𝐞𝐫 𝐰𝐡𝐨 𝐡𝐚𝐬 𝐰𝐫𝐢𝐭𝐭𝐞𝐧 𝐚𝐧 𝐚𝐫𝐭𝐢𝐜𝐥𝐞 𝐭𝐡𝐚𝐭 𝐜𝐫𝐢𝐭𝐢𝐜𝐢𝐳𝐞𝐬 𝐭𝐡𝐞 𝐨𝐛𝐯𝐢𝐨𝐮𝐬 𝐬𝐜𝐢𝐞𝐧𝐭𝐢𝐟𝐢𝐜 𝐚𝐧𝐝 𝐞𝐜𝐨𝐧𝐨𝐦𝐢𝐜 𝐰𝐚𝐬𝐭𝐞 𝐚𝐬𝐬𝐨𝐜𝐢𝐚𝐭𝐞𝐝 𝐰𝐢𝐭𝐡 𝐓𝐚𝐫𝐠𝐞𝐭𝐞𝐝 𝐀𝐥𝐩𝐡𝐚 𝐓𝐡𝐞𝐫𝐚𝐩𝐲, 𝐚 𝐜𝐚𝐧𝐜𝐞𝐫 𝐭𝐫𝐞𝐚𝐭𝐦𝐞𝐧𝐭 𝐭𝐡𝐚𝐭 𝐢𝐧𝐯𝐨𝐥𝐯𝐞𝐬 𝐚𝐝𝐦𝐢𝐧𝐢𝐬𝐭𝐞𝐫𝐢𝐧𝐠 𝐚 𝐫𝐚𝐝𝐢𝐨𝐚𝐜𝐭𝐢𝐯𝐞 𝐝𝐫𝐮𝐠 𝐭𝐨 𝐚 𝐯𝐞𝐫𝐲 𝐬𝐢𝐜𝐤 𝐩𝐚𝐭𝐢𝐞𝐧𝐭 𝐛𝐲 𝐢𝐧𝐭𝐫𝐚𝐯𝐞𝐧𝐨𝐮𝐬 𝐝𝐫𝐢𝐩? The scientific argument in the criticism is sound, but the medical journal ecosystem has […]

Health insurance coverage in the USA is declining, driven by the expiration of enhanced Affordable Care Act (ACA) subsidies and post-pandemic Medicaid unwinding. Millions are dropping out of the market due to unaffordable premiums, while those who retain plans face narrower networks, stricter coverage denials, and higher out-of-pocket costs. The decline in US health insurance […]

Dear Drs. xxxxxxxxxxxx and xxxxxxxxxxxxxxx, I write to inquire whether the Journal of Clinical Epidemiology would consider a Perspective manuscript entitled xxxxxxxxxxxxxxxxxxxxxxxx. The manuscript (~5,100 words, 37 references) addresses a problem that experienced clinical epidemiologists and HTA reviewers recognize but that the published literature has been reluctant to name directly: when Phase 3 trials produce […]

Adeno-associated virus serotype 9 (AAV9) is highly valued in gene therapy because it can cross the blood-brain barrier. It is primarily used to treat monogenic neurological and neuromuscular disorders, most notably Spinal Muscular Atrophy (SMA). AAV9 vectors deliver functional genetic material to replace or suppress faulty genes. Approved treatments and advanced clinical trials using AAV9 […]