Archive for April, 2026

Accelerating the Orphan GPCR Pipeline: GPR149 as a Case Study in Dual-Domain Target Validation

Posted by Michael A. S. Guth on April 30th, 2026

https://doi.org/10.1016/j.drudis.2026.104678ย  Free download of the article using this link until June 16:ย  https://authors.elsevier.com/a/1n0uP4r9Rkz1l6 Highlights New four-pillar framework accelerates deorphanization of dark GPCR targets. (77 chars) GPR149 structural analysis identifies non-canonical ERY and DPxxF motifs. (76 chars) Path-agnostic screening bypasses traditional Gi/oย signaling limitations. (75 chars) Integrated CNS and metabolic mapping reveals GPR149โ€ฒs dual-domain value. (76 chars) […]

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The Future of PTSD Treatment: Beyond the Daily Pill

Posted by Michael A. S. Guth on April 5th, 2026

We are currently witnessing a “Neuroplasticity Revolution” that is redefining the landscape of mental health care. Traditional treatments have often focused on managing the symptoms of PTSD through daily medication, but the focus is now shifting toward remodeling the brain’s actual architecture. This approach aims to fix the “hardware” of the brain, rather than just […]

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๐‡๐ž๐š๐๐ฅ๐ข๐ง๐ž: ๐๐ž๐ฒ๐จ๐ง๐ ๐’๐ฒ๐ง๐š๐ฉ๐ฌ๐ž๐ฌ: ๐“๐ก๐ž ๐‘๐จ๐ฅ๐ž ๐จ๐Ÿ ๐Œ๐ฒ๐ž๐ฅ๐ข๐ง ๐๐ฅ๐š๐ฌ๐ญ๐ข๐œ๐ข๐ญ๐ฒ ๐š๐ง๐ ๐๐ž๐ฎ๐ซ๐จ๐ญ๐ซ๐จ๐ฉ๐ก๐ข๐œ ๐’๐ข๐ ๐ง๐š๐ฅ๐ข๐ง๐  ๐ข๐ง ๐๐“๐’๐ƒ ๐๐š๐ญ๐ก๐จ๐ฉ๐ก๐ฒ๐ฌ๐ข๐จ๐ฅ๐จ๐ ๐ฒ

Posted by Michael A. S. Guth on April 5th, 2026

Recent evidence published in Revista de Neurologรญa highlights a critical shift in our understanding of Post-Traumatic Stress Disorder (PTSD). While traditional models focus heavily on synaptic weakening, new data underscores the sophisticated role of myelin plasticity within the amygdala-hippocampus-prefrontal cortex (PFC) circuit. This remodeling is not merely a byproduct of trauma but a fundamental mechanism […]

Posted in Neuroplasticity Comments Off on ๐‡๐ž๐š๐๐ฅ๐ข๐ง๐ž: ๐๐ž๐ฒ๐จ๐ง๐ ๐’๐ฒ๐ง๐š๐ฉ๐ฌ๐ž๐ฌ: ๐“๐ก๐ž ๐‘๐จ๐ฅ๐ž ๐จ๐Ÿ ๐Œ๐ฒ๐ž๐ฅ๐ข๐ง ๐๐ฅ๐š๐ฌ๐ญ๐ข๐œ๐ข๐ญ๐ฒ ๐š๐ง๐ ๐๐ž๐ฎ๐ซ๐จ๐ญ๐ซ๐จ๐ฉ๐ก๐ข๐œ ๐’๐ข๐ ๐ง๐š๐ฅ๐ข๐ง๐  ๐ข๐ง ๐๐“๐’๐ƒ ๐๐š๐ญ๐ก๐จ๐ฉ๐ก๐ฒ๐ฌ๐ข๐จ๐ฅ๐จ๐ ๐ฒ
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In the 1950s, my physicist father met with Albert Einstein at the Institute for Advanced Study to discuss unified field theory.

Posted by Michael A. S. Guth on April 5th, 2026

In the 1950s, my physicist father, Eugene Guth, met with Albert Einstein at the Institute for Advanced Study to discuss unified field theory. Einstein, it turned out, was more interested in the philosophy of physics than the math, a topic equally of interest to my dad.ย  See https://michaelguth.com/family/HistoryofPhysicsbyEugeneGuth.htm Mathematics and philosophy of physics have relevance […]

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The FDA approval of Kresladi (marnetegragene autotemcel) on March 26, 2026

Posted by Michael A. S. Guth on April 2nd, 2026

The FDA approval of Kresladi (marnetegragene autotemcel) on March 26, 2026, is indeed a watershed moment for Rocket Pharmaceuticals and the LAD-I community. However, your question regarding the cost per patient touches on the most complex challenge in modern medicine: the “one-and-done” curative price tag. While Rocket Pharmaceuticals has not yet publicly released the official […]

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Eden Alternativeย and theย Butterfly Model Instead of Nursing Home Care

Posted by Michael A. S. Guth on April 2nd, 2026

Both theย Eden Alternativeย and theย Butterfly Modelย are philosophies of care that seek to radically transform the traditional, institutional nursing home into a vibrant, person-centered home. Moira Welsh features both inย Happily Ever Olderย as leading examples of successful, humane care modelsย . While they share the same goal of eliminating loneliness, helplessness, and boredom, their origins and methods differ. Hereโ€™s […]

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๐…๐จ๐œ๐ฎ๐ฌ๐ข๐ง๐  ๐จ๐ง ๐›๐ž๐ญ๐ญ๐ž๐ซ ๐š๐ฅ๐ญ๐ž๐ซ๐ง๐š๐ญ๐ข๐ฏ๐ž๐ฌ ๐ญ๐จ ๐ฌ๐ก๐ข๐ฉ๐ฉ๐ข๐ง๐  ๐จ๐Ÿ๐Ÿ ๐ž๐ฅ๐๐ž๐ซ๐ฅ๐ฒ ๐ฉ๐š๐ซ๐ž๐ง๐ญ๐ฌ ๐ญ๐จ ๐ง๐ฎ๐ซ๐ฌ๐ข๐ง๐  ๐ก๐จ๐ฆ๐ž๐ฌ

Posted by Michael A. S. Guth on April 2nd, 2026

๐…๐จ๐œ๐ฎ๐ฌ๐ข๐ง๐  ๐จ๐ง ๐›๐ž๐ญ๐ญ๐ž๐ซ ๐š๐ฅ๐ญ๐ž๐ซ๐ง๐š๐ญ๐ข๐ฏ๐ž๐ฌ ๐ญ๐จ ๐ฌ๐ก๐ข๐ฉ๐ฉ๐ข๐ง๐  ๐จ๐Ÿ๐Ÿ ๐ž๐ฅ๐๐ž๐ซ๐ฅ๐ฒ ๐ฉ๐š๐ซ๐ž๐ง๐ญ๐ฌ ๐ญ๐จ ๐ง๐ฎ๐ซ๐ฌ๐ข๐ง๐  ๐ก๐จ๐ฆ๐ž๐ฌ. Moira Welsh’sย HAPPILY EVER OLDERย is a hopeful investigative work that serves as a “blueprint for change” in long-term careย . Instead of focusing on common horror stories, Welsh travels across North America and Europe to find facilities that have successfully replaced institutional “warehousing” with vibrant […]

Posted in About, Regulatory Medical Writing Comments Off on ๐…๐จ๐œ๐ฎ๐ฌ๐ข๐ง๐  ๐จ๐ง ๐›๐ž๐ญ๐ญ๐ž๐ซ ๐š๐ฅ๐ญ๐ž๐ซ๐ง๐š๐ญ๐ข๐ฏ๐ž๐ฌ ๐ญ๐จ ๐ฌ๐ก๐ข๐ฉ๐ฉ๐ข๐ง๐  ๐จ๐Ÿ๐Ÿ ๐ž๐ฅ๐๐ž๐ซ๐ฅ๐ฒ ๐ฉ๐š๐ซ๐ž๐ง๐ญ๐ฌ ๐ญ๐จ ๐ง๐ฎ๐ซ๐ฌ๐ข๐ง๐  ๐ก๐จ๐ฆ๐ž๐ฌ
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