Archive for the ‘Featured’ Category

๐“๐ก๐ž “๐’๐ก๐š๐ฉ๐ž” ๐จ๐Ÿ ๐ˆ๐ง๐ง๐จ๐ฏ๐š๐ญ๐ข๐จ๐ง: ๐–๐ก๐ฒ ๐Œ๐จ๐ซ๐ฉ๐ก๐จ๐ฅ๐จ๐ ๐ข๐œ๐š๐ฅ ๐Œ๐š๐ซ๐ค๐ž๐ซ๐ฌ ๐š๐ซ๐ž ๐ญ๐ก๐ž ๐…๐ฎ๐ญ๐ฎ๐ซ๐ž ๐จ๐Ÿ ๐‘๐–๐„ ๐ข๐ง ๐‚๐๐’

Posted by Michael A. S. Guth on February 23rd, 2026

๐‡๐ž๐š๐๐ฅ๐ข๐ง๐ž: ๐“๐ก๐ž “๐’๐ก๐š๐ฉ๐ž” ๐จ๐Ÿ ๐ˆ๐ง๐ง๐จ๐ฏ๐š๐ญ๐ข๐จ๐ง: ๐–๐ก๐ฒ ๐Œ๐จ๐ซ๐ฉ๐ก๐จ๐ฅ๐จ๐ ๐ข๐œ๐š๐ฅ ๐Œ๐š๐ซ๐ค๐ž๐ซ๐ฌ ๐š๐ซ๐ž ๐ญ๐ก๐ž ๐…๐ฎ๐ญ๐ฎ๐ซ๐ž ๐จ๐Ÿ ๐‘๐–๐„ ๐ข๐ง ๐‚๐๐’ In the high-stakes world of CNS drug discovery and Real-World Evidence (RWE), weโ€™ve leaned on behavioral scales for too long. But in 2026, the data is clear: Morphological Biomarkers are the new gold standard. Recent advancements in Geometric Morphometrics prove […]

Posted in Featured, Neuroplasticity Comments Off on ๐“๐ก๐ž “๐’๐ก๐š๐ฉ๐ž” ๐จ๐Ÿ ๐ˆ๐ง๐ง๐จ๐ฏ๐š๐ญ๐ข๐จ๐ง: ๐–๐ก๐ฒ ๐Œ๐จ๐ซ๐ฉ๐ก๐จ๐ฅ๐จ๐ ๐ข๐œ๐š๐ฅ ๐Œ๐š๐ซ๐ค๐ž๐ซ๐ฌ ๐š๐ซ๐ž ๐ญ๐ก๐ž ๐…๐ฎ๐ญ๐ฎ๐ซ๐ž ๐จ๐Ÿ ๐‘๐–๐„ ๐ข๐ง ๐‚๐๐’
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Beyond the BBB: Mapping the 2026 Milestone Year for Neuroscience

Posted by Michael A. S. Guth on February 18th, 2026

Beyond the BBB: Mapping the 2026 Milestone Year for Neuroscience.ย  As we move through Q1, all eyes in the neuroscience community are on April 5, 2026โ€”the PDUFA target action date for tividenofusp alfa (DNL310). If approved, tividenofusp alfa will be a watershed moment: the first commercial validation of a Transport Vehicle (TV) enabled enzyme replacement […]

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“Chemo Brain” and Diabetes Research

Posted by Michael A. S. Guth on February 10th, 2026

Is the Next Breakthrough in “Chemo Brain” Treatment Hiding in Diabetes Research? For cancer survivors, the battle often doesn’t end with remission. Chemotherapy-Induced Cognitive Impairment (CICI)โ€”widely known as “Chemo Brain”โ€”remains one of the most debilitating long-term side effects of treatment, affecting memory, executive function, and attention. While the clinical impact is well-documented, therapeutic options remain […]

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COVID-19 Treatment Strategies: Dec 2025 update

Posted by Michael A. S. Guth on December 13th, 2025
Moving Simulation of SARS-CoV-2 Delta Variant

Image:ย  Computerย Simulation of SARS-CoV-2. Reprinted with kind permission of Janet Iwasa of http://animationlab.utah.edu/cova Should I Get a COVID-19 Vaccine in December 2025 or January 2026? As we move through the winter of 2025-2026, the question of whether to get a COVID-19 vaccine is highly relevant, especially as respiratory viruses typically peak during this time. The […]

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The State of Cancer Research

Posted by Michael A. S. Guth on August 7th, 2021

And we already know how small a role the cancer gene plays in the onset of cancer: there has been an 8-fold to 17-fold increase in the incidence of cancer in the last hundred years, but not even one-millionth of 1 percent of that increase can be related to genes.

Genes evolve over hundreds of thousands (if not millions) of years, which means that the so-called cancer gene has had no impact on the huge increase weโ€™ve seen since 1900. Virtually 90 percent of the cancer that we see today cannot possibly have anything to do with genes.

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Clinical Evaluation Report (CER) Medical Writer

Posted by Michael A. S. Guth on March 15th, 2020

Perform Clinical Evaluations and write/update Clinical Evaluation Reports (CERs) and Clinical Evaluation Plans (CEPs)ย  in compliance with the European Union (EU) Medical Device Regulation (MDR).ย  Perform Literature Reviews using PubMed, Embase, Cochrane Library, and similar databases. Interpret the current, new, and changing requirements for clinical research—including heightened restrictions on product equivalency—to ensure the proper clinical […]

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Combining Research, Safety, and Epidemiology

Posted by Michael A. S. Guth on October 23rd, 2018

Risk Management Consulting (RMC), a health services research firm, offers Research, Safety, and Epidemiology services with experience in the healthcare consulting and biopharmaceutical industries. RMC provides the health care system, biopharmaceutical industry, academia, and the Federal Government with “real-world” data to improve the quality, safety, and affordability of healthcare. RMC’s projects range from retrospective to […]

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Declining incidence of major diseases: heart disease, hip fractures, colon cancer, etc.

Posted by Michael A. S. Guth on October 18th, 2018

“Screening, they say, is only part of the story. โ€œThe magnitude of the changes alone suggests that other factors must be involved,โ€ they wrote. None of the studies showing the effect of increased screening for colon cancer have indicated a 50 percent reduction in mortality, they wrote, โ€œnor have trials for screening for any type […]

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