Niacinamide is currently one of the most celebrated ingredients in skincare, praised in every beauty and wellness journal for its ability to strengthen the skin barrier topically. But lately, there has been a lot of buzz about taking it orally to prevent skin cancer. Does the science back up the hype? Yes—but with some major […]

Real-World Evidence vs. Meta-Analyses: The Evolving Debate on Nicotinamide for Skin Cancer Chemoprevention The clinical utility of oral nicotinamide (NAM) for non-melanoma skin cancer (NMSC) chemoprevention remains a prime example of the tension between landmark RCT data, real-world evidence (RWE), and systematic evidence syntheses. While the 2015 Phase 3 ONTRAC trial established a 23% reduction […]

𝗪𝗵𝘆 𝘁𝗵𝗲 𝗙𝘂𝘁𝘂𝗿𝗲 𝗼𝗳 𝗕𝗶𝗼𝘁𝗲𝗰𝗵 𝗗𝗲𝗽𝗲𝗻𝗱𝘀 𝗼𝗻 𝗕𝗿𝗶𝗱𝗴𝗶𝗻𝗴 “𝗪𝗲𝘁𝘄𝗮𝗿𝗲” 𝗮𝗻𝗱 𝗦𝗼𝗳𝘁𝘄𝗮𝗿𝗲.𝗧𝗵𝗲 𝗡𝗲𝘅𝘁 𝗟𝗲𝗮𝗽 𝗶𝗻 𝗔𝗜: 𝗚𝗿𝗼𝘂𝗻𝗱𝗶𝗻𝗴 𝗠𝗮𝗰𝗵𝗶𝗻𝗲 𝗟𝗲𝗮𝗿𝗻𝗶𝗻𝗴 𝗶𝗻 𝗕𝗶𝗼𝗹𝗼𝗴𝗶𝗰𝗮𝗹 𝗣𝗵𝘆𝘀𝗶𝗰𝘀. 𝗙𝗿𝗼𝗺 𝗢𝗯𝘀𝗲𝗿𝘃𝗮𝘁𝗶𝗼𝗻 𝘁𝗼 𝗖𝗼𝗻𝘁𝗿𝗼𝗹: 𝗧𝗵𝗲 𝗡𝗲𝘄 𝗘𝗿𝗮 𝗼𝗳 𝗖𝗼𝗺𝗽𝘂𝘁𝗮𝘁𝗶𝗼𝗻𝗮𝗹 𝗡𝗲𝘂𝗿𝗼𝘀𝗰𝗶𝗲𝗻𝗰𝗲. The future of AI and biotech isn’t just about collecting more data; it’s about building better models of the underlying “physics” of the system. […]

𝐎𝐫𝐝𝐞𝐫 𝐟𝐫𝐨𝐦 𝐂𝐡𝐚𝐨𝐬: 𝐇𝐨𝐰 𝐑𝐚𝐧𝐝𝐨𝐦𝐧𝐞𝐬𝐬 𝐃𝐫𝐢𝐯𝐞𝐬 𝐍𝐞𝐮𝐫𝐚𝐥 𝐋𝐞𝐚𝐫𝐧𝐢𝐧𝐠 𝐚𝐧𝐝 𝐏𝐥𝐚𝐬𝐭𝐢𝐜𝐢𝐭𝐲. 𝐖𝐡𝐲 “𝐍𝐨𝐢𝐬𝐞” 𝐢𝐬 𝐭𝐡𝐞 𝐒𝐞𝐜𝐫𝐞𝐭 𝐒𝐚𝐮𝐜𝐞 𝐨𝐟 𝐇𝐮𝐦𝐚𝐧 𝐈𝐧𝐭𝐞𝐥𝐥𝐢𝐠𝐞𝐧𝐜𝐞. 𝐃𝐞𝐜𝐨𝐝𝐢𝐧𝐠 𝐔𝐧𝐜𝐞𝐫𝐭𝐚𝐢𝐧𝐭𝐲: 𝐔𝐬𝐢𝐧𝐠 𝐒𝐭𝐨𝐜𝐡𝐚𝐬𝐭𝐢𝐜 𝐄𝐪𝐮𝐚𝐭𝐢𝐨𝐧𝐬 𝐭𝐨 𝐔𝐧𝐝𝐞𝐫𝐬𝐭𝐚𝐧𝐝 𝐭𝐡𝐞 𝐁𝐫𝐚𝐢𝐧’𝐬 𝐂𝐡𝐚𝐨𝐬. In most engineering disciplines, “noise” is an enemy to be filtered out or minimized. However, in the human brain, noise is a fundamental feature of the […]