Archive for March, 2026

A New Blueprint for Turning an Orphan Brain Receptor into a Blockbuster Drug Target

Posted by Michael A. S. Guth on March 30th, 2026

Forthcoming inย Drug Discovery Today: A New Blueprint for Turning an Orphan Brain Receptor into a Blockbuster Drug Target I am pleased to announce that my article, “Accelerating the Orphan GPCR Pipeline: GPR149 as a Case Study in Dual-Domain Target Validation,” has been accepted for publication inย Drug Discovery Today, a leading journal for pharmaceutical strategy and […]

Posted in Neuroplasticity, Pharma and Medical Device Comments Off on A New Blueprint for Turning an Orphan Brain Receptor into a Blockbuster Drug Target
Read More »

๐…๐จ๐œ๐ฎ๐ฌ ๐จ๐ง ๐„๐ฆ๐ฉ๐จ๐ฐ๐ž๐ซ๐ฆ๐ž๐ง๐ญ & ๐„๐๐ฎ๐œ๐š๐ญ๐ข๐จ๐ง: ๐€๐ซ๐ž ๐ฒ๐จ๐ฎ ๐›๐ฎ๐ข๐ฅ๐๐ข๐ง๐  ๐ฒ๐จ๐ฎ๐ซ ๐›๐ซ๐š๐ข๐ง ๐ฎ๐ฉ, ๐จ๐ซ ๐š๐ซ๐ž ๐ฒ๐จ๐ฎ ๐ฅ๐ž๐ญ๐ญ๐ข๐ง๐  ๐ข๐ญ ๐›๐ซ๐ž๐š๐ค ๐๐จ๐ฐ๐ง?

Posted by Michael A. S. Guth on March 27th, 2026

๐…๐จ๐œ๐ฎ๐ฌ ๐จ๐ง ๐„๐ฆ๐ฉ๐จ๐ฐ๐ž๐ซ๐ฆ๐ž๐ง๐ญ & ๐„๐๐ฎ๐œ๐š๐ญ๐ข๐จ๐ง: ๐€๐ซ๐ž ๐ฒ๐จ๐ฎ ๐›๐ฎ๐ข๐ฅ๐๐ข๐ง๐  ๐ฒ๐จ๐ฎ๐ซ ๐›๐ซ๐š๐ข๐ง ๐ฎ๐ฉ, ๐จ๐ซ ๐š๐ซ๐ž ๐ฒ๐จ๐ฎ ๐ฅ๐ž๐ญ๐ญ๐ข๐ง๐  ๐ข๐ญ ๐›๐ซ๐ž๐š๐ค ๐๐จ๐ฐ๐ง? The concept of Cognitive Reserve is the single most empowering framework for understanding how we age. “Cognitive Reserve” is the buffer your brain buildsโ€”a dynamic network of strong neural connections that protects your ability to think, remember, […]

Posted in Regulatory Medical Writing Comments Off on ๐…๐จ๐œ๐ฎ๐ฌ ๐จ๐ง ๐„๐ฆ๐ฉ๐จ๐ฐ๐ž๐ซ๐ฆ๐ž๐ง๐ญ & ๐„๐๐ฎ๐œ๐š๐ญ๐ข๐จ๐ง: ๐€๐ซ๐ž ๐ฒ๐จ๐ฎ ๐›๐ฎ๐ข๐ฅ๐๐ข๐ง๐  ๐ฒ๐จ๐ฎ๐ซ ๐›๐ซ๐š๐ข๐ง ๐ฎ๐ฉ, ๐จ๐ซ ๐š๐ซ๐ž ๐ฒ๐จ๐ฎ ๐ฅ๐ž๐ญ๐ญ๐ข๐ง๐  ๐ข๐ญ ๐›๐ซ๐ž๐š๐ค ๐๐จ๐ฐ๐ง?
Read More »

Authority, Long-term Reach, and “Save” Signals

Posted by Michael A. S. Guth on March 24th, 2026

New evidence provides a stronger link between chronic anxiety and future neurocognitive decline, demanding a re-evaluation of how we approach dementia prevention in clinical practice. A major updated meta-analysis, now available in the Journal of Clinical Medicine, confirms that anxiety is significantly associated with an increased risk of all-cause dementia. This extensive study, spanning nine […]

Posted in Featured, Neuroplasticity, Regulatory Medical Writing Comments Off on Authority, Long-term Reach, and “Save” Signals
Read More »

๐…๐จ๐œ๐ฎ๐ฌ ๐จ๐ง ๐€๐œ๐ญ๐ข๐จ๐ง & ๐’๐ญ๐ซ๐š๐ญ๐ž๐ ๐ฒ: Positive Neuroplasticity

Posted by Michael A. S. Guth on March 24th, 2026

๐…๐จ๐œ๐ฎ๐ฌ ๐จ๐ง ๐€๐œ๐ญ๐ข๐จ๐ง & ๐’๐ญ๐ซ๐š๐ญ๐ž๐ ๐ฒ: ๐–๐ž ๐จ๐Ÿ๐ญ๐ž๐ง ๐ญ๐ก๐ข๐ง๐ค ๐จ๐Ÿ ๐ฆ๐ž๐ง๐ญ๐š๐ฅ ๐ก๐ž๐š๐ฅ๐ญ๐ก ๐š๐ง๐ ๐ฅ๐จ๐ง๐ -๐ญ๐ž๐ซ๐ฆ ๐›๐ซ๐š๐ข๐ง ๐ก๐ž๐š๐ฅ๐ญ๐ก ๐š๐ฌ ๐ญ๐ฐ๐จ ๐ฌ๐ž๐ฉ๐š๐ซ๐š๐ญ๐ž ๐œ๐จ๐ง๐œ๐ž๐ฉ๐ญ๐ฌ, ๐›๐ฎ๐ญ ๐ง๐ž๐ฐ ๐ซ๐ž๐ฌ๐ž๐š๐ซ๐œ๐ก ๐ฌ๐ก๐จ๐ฐ๐ฌ ๐ญ๐ก๐ž๐ฒ ๐š๐ซ๐ž ๐๐ž๐ž๐ฉ๐ฅ๐ฒ ๐ข๐ง๐ญ๐ž๐ซ๐œ๐จ๐ง๐ง๐ž๐œ๐ญ๐ž๐. If you are managing chronic anxiety, you are managing a significant, preventable risk factor for your cognitive future. A comprehensive analysis of data from nearly 30,000 people found […]

Posted in Neuroplasticity Comments Off on ๐…๐จ๐œ๐ฎ๐ฌ ๐จ๐ง ๐€๐œ๐ญ๐ข๐จ๐ง & ๐’๐ญ๐ซ๐š๐ญ๐ž๐ ๐ฒ: Positive Neuroplasticity
Read More »

SuperAgers Produce More Neuroblasts

Posted by Michael A. S. Guth on March 2nd, 2026

The dogma that neurogenesis slows to a trickle in the aging human brain has been significantly challenged this week. A groundbreaking study published in Nature (February 25, 2026), led by scientists at the University of Illinois Chicago and the Northwestern University SuperAger Program, reveals that SuperAgers produce neuroblasts at rates far higher than their age-matched […]

Posted in Regulatory Medical Writing Comments Off on SuperAgers Produce More Neuroblasts
Read More »