Archive for the ‘About’ Category

Accelerating the Orphan GPCR Pipeline: GPR149 as a Case Study in Dual-Domain Target Validation

Posted by Michael A. S. Guth on April 30th, 2026

https://doi.org/10.1016/j.drudis.2026.104678  Free download of the article using this link until June 16:  https://authors.elsevier.com/a/1n0uP4r9Rkz1l6 Highlights New four-pillar framework accelerates deorphanization of dark GPCR targets. (77 chars) GPR149 structural analysis identifies non-canonical ERY and DPxxF motifs. (76 chars) Path-agnostic screening bypasses traditional Gi/o signaling limitations. (75 chars) Integrated CNS and metabolic mapping reveals GPR149′s dual-domain value. (76 chars) […]

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In the 1950s, my physicist father met with Albert Einstein at the Institute for Advanced Study to discuss unified field theory.

Posted by Michael A. S. Guth on April 5th, 2026

In the 1950s, my physicist father, Eugene Guth, met with Albert Einstein at the Institute for Advanced Study to discuss unified field theory. Einstein, it turned out, was more interested in the philosophy of physics than the math, a topic equally of interest to my dad.  See https://michaelguth.com/family/HistoryofPhysicsbyEugeneGuth.htm Mathematics and philosophy of physics have relevance […]

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𝐅𝐨𝐜𝐮𝐬𝐢𝐧𝐠 𝐨𝐧 𝐛𝐞𝐭𝐭𝐞𝐫 𝐚𝐥𝐭𝐞𝐫𝐧𝐚𝐭𝐢𝐯𝐞𝐬 𝐭𝐨 𝐬𝐡𝐢𝐩𝐩𝐢𝐧𝐠 𝐨𝐟𝐟 𝐞𝐥𝐝𝐞𝐫𝐥𝐲 𝐩𝐚𝐫𝐞𝐧𝐭𝐬 𝐭𝐨 𝐧𝐮𝐫𝐬𝐢𝐧𝐠 𝐡𝐨𝐦𝐞𝐬

Posted by Michael A. S. Guth on April 2nd, 2026

𝐅𝐨𝐜𝐮𝐬𝐢𝐧𝐠 𝐨𝐧 𝐛𝐞𝐭𝐭𝐞𝐫 𝐚𝐥𝐭𝐞𝐫𝐧𝐚𝐭𝐢𝐯𝐞𝐬 𝐭𝐨 𝐬𝐡𝐢𝐩𝐩𝐢𝐧𝐠 𝐨𝐟𝐟 𝐞𝐥𝐝𝐞𝐫𝐥𝐲 𝐩𝐚𝐫𝐞𝐧𝐭𝐬 𝐭𝐨 𝐧𝐮𝐫𝐬𝐢𝐧𝐠 𝐡𝐨𝐦𝐞𝐬. Moira Welsh’s HAPPILY EVER OLDER is a hopeful investigative work that serves as a “blueprint for change” in long-term care . Instead of focusing on common horror stories, Welsh travels across North America and Europe to find facilities that have successfully replaced institutional “warehousing” with vibrant […]

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Posted by Michael A. S. Guth on December 19th, 2025

The Institute for Neuroplasticity Research is dedicated to pioneering the next frontier of neurological therapeutics by harnessing the brain’s innate capacity for change. We operate at the critical intersection of advanced science and strategic development, focusing on transformative modalities like Cell Replacement Therapy and novel neuromodulation. Our core mission is to de-risk and accelerate the path of […]

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