Archive for the ‘About’ Category

TAX508 Personal Income Taxation (Summer Term 2026)

Posted by Michael A. S. Guth on July 7th, 2026

I am pleased to share that for the summer 2026 academic term, I am teaching TAX508: Taxation of Individuals at William Howard Taft University. This graduate-level course provides a comprehensive framework for navigating the complex statutory, regulatory, and judicial realities governing federal individual income taxation. Guided by the fundamental powers established under the Sixteenth Amendment, […]

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Alzheimer’s Dual Sequestration Hypothesis

Posted by Michael A. S. Guth on June 25th, 2026

๐๐ž๐ฐ ๐๐ฎ๐›๐ฅ๐ข๐œ๐š๐ญ๐ข๐จ๐ง ๐ข๐ง ๐…๐ซ๐ž๐ž ๐๐ž๐ฎ๐ซ๐จ๐ฉ๐š๐ญ๐ก๐จ๐ฅ๐จ๐ ๐ฒ (๐‰๐ฎ๐ง๐ž ๐Ÿ๐ŸŽ๐Ÿ๐Ÿ”) ๐ˆ ๐š๐ฆ ๐ฉ๐ฅ๐ž๐š๐ฌ๐ž๐ ๐ญ๐จ ๐ฌ๐ก๐š๐ซ๐ž ๐จ๐ฎ๐ซ ๐ฅ๐š๐ญ๐ž๐ฌ๐ญ ๐œ๐ฅ๐ข๐ง๐ข๐œ๐จ๐ฉ๐š๐ญ๐ก๐จ๐ฅ๐จ๐ ๐ข๐œ๐š๐ฅ ๐ฎ๐ฉ๐๐š๐ญ๐ž ๐š๐๐๐ซ๐ž๐ฌ๐ฌ๐ข๐ง๐  ๐š ๐ฉ๐ž๐ซ๐ฌ๐ข๐ฌ๐ญ๐ž๐ง๐ญ ๐ฉ๐š๐ซ๐š๐๐จ๐ฑ ๐ข๐ง ๐€๐ฅ๐ณ๐ก๐ž๐ข๐ฆ๐ž๐ซ’๐ฌ ๐๐ข๐ฌ๐ž๐š๐ฌ๐ž: ๐ฐ๐ก๐ฒ ๐ญ๐ก๐ž๐ซ๐š๐ฉ๐ข๐ž๐ฌ ๐ญ๐š๐ซ๐ ๐ž๐ญ๐ข๐ง๐  ๐ญ๐ก๐ž ๐ซ๐ž๐ฆ๐จ๐ฏ๐š๐ฅ ๐จ๐Ÿ ๐š๐ฆ๐ฒ๐ฅ๐จ๐ข๐-ฮฒ ๐ฉ๐ฅ๐š๐ช๐ฎ๐ž๐ฌ ๐š๐ง๐ ๐ญ๐š๐ฎ ๐ญ๐š๐ง๐ ๐ฅ๐ž๐ฌ ๐œ๐จ๐ง๐ฌ๐ข๐ฌ๐ญ๐ž๐ง๐ญ๐ฅ๐ฒ ๐ฌ๐ก๐จ๐ฐ ๐š ๐œ๐ซ๐ข๐ญ๐ข๐œ๐š๐ฅ ๐๐ข๐ฌ๐ฌ๐จ๐œ๐ข๐š๐ญ๐ข๐จ๐ง ๐Ÿ๐ซ๐จ๐ฆ ๐œ๐จ๐ซ๐ž ๐œ๐ฅ๐ข๐ง๐ข๐œ๐š๐ฅ ๐ฉ๐š๐ญ๐ก๐จ๐ ๐ž๐ง๐ž๐ฌ๐ข๐ฌ. ๐ˆ๐ง “๐€๐ฅ๐ณ๐ก๐ž๐ข๐ฆ๐ž๐ซ’๐ฌ ๐๐ข๐ฌ๐ž๐š๐ฌ๐ž ๐ข๐ง ๐ญ๐ก๐ž ๐๐ฅ๐š๐ฌ๐ญ๐ข๐œ๐ž๐ง๐ž ๐ž๐ซ๐š: ๐š ๐œ๐ฅ๐ข๐ง๐ข๐œ๐จ๐ฉ๐š๐ญ๐ก๐จ๐ฅ๐จ๐ ๐ข๐œ๐š๐ฅ ๐ฎ๐ฉ๐๐š๐ญ๐ž ๐จ๐ง ๐ญ๐ก๐ž […]

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National Alzheimer’s Prevention Policy

Posted by Michael A. S. Guth on May 30th, 2026

“๐‰๐ฎ๐๐ ๐ž ๐š ๐ฆ๐š๐ง ๐›๐ฒ ๐ก๐ข๐ฌ ๐ช๐ฎ๐ž๐ฌ๐ญ๐ข๐จ๐ง๐ฌ ๐ซ๐š๐ญ๐ก๐ž๐ซ ๐ญ๐ก๐š๐ง ๐›๐ฒ ๐ก๐ข๐ฌ ๐š๐ง๐ฌ๐ฐ๐ž๐ซ๐ฌ.” – ๐•๐จ๐ฅ๐ญ๐š๐ข๐ซ๐žย  ย  ย So hereโ€™s my question: Should a national policy treat perfectly healthy, โ€œat riskโ€ people for Alzheimerโ€™s before they show a single symptom? Iโ€™ve spent the last several months researching and writing exactly that โ€” a new national prophylaxis framework for Alzheimerโ€™s […]

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Accelerating the Orphan GPCR Pipeline: GPR149 as a Case Study in Dual-Domain Target Validation

Posted by Michael A. S. Guth on April 30th, 2026

https://doi.org/10.1016/j.drudis.2026.104678ย  Free download of the article using this link until June 16:ย  https://authors.elsevier.com/a/1n0uP4r9Rkz1l6 Highlights New four-pillar framework accelerates deorphanization of dark GPCR targets. (77 chars) GPR149 structural analysis identifies non-canonical ERY and DPxxF motifs. (76 chars) Path-agnostic screening bypasses traditional Gi/oย signaling limitations. (75 chars) Integrated CNS and metabolic mapping reveals GPR149โ€ฒs dual-domain value. (76 chars) […]

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In the 1950s, my physicist father met with Albert Einstein at the Institute for Advanced Study to discuss unified field theory.

Posted by Michael A. S. Guth on April 5th, 2026

In the 1950s, my physicist father, Eugene Guth, met with Albert Einstein at the Institute for Advanced Study to discuss unified field theory. Einstein, it turned out, was more interested in the philosophy of physics than the math, a topic equally of interest to my dad.ย  See https://michaelguth.com/family/HistoryofPhysicsbyEugeneGuth.htm Mathematics and philosophy of physics have relevance […]

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๐…๐จ๐œ๐ฎ๐ฌ๐ข๐ง๐  ๐จ๐ง ๐›๐ž๐ญ๐ญ๐ž๐ซ ๐š๐ฅ๐ญ๐ž๐ซ๐ง๐š๐ญ๐ข๐ฏ๐ž๐ฌ ๐ญ๐จ ๐ฌ๐ก๐ข๐ฉ๐ฉ๐ข๐ง๐  ๐จ๐Ÿ๐Ÿ ๐ž๐ฅ๐๐ž๐ซ๐ฅ๐ฒ ๐ฉ๐š๐ซ๐ž๐ง๐ญ๐ฌ ๐ญ๐จ ๐ง๐ฎ๐ซ๐ฌ๐ข๐ง๐  ๐ก๐จ๐ฆ๐ž๐ฌ

Posted by Michael A. S. Guth on April 2nd, 2026

๐…๐จ๐œ๐ฎ๐ฌ๐ข๐ง๐  ๐จ๐ง ๐›๐ž๐ญ๐ญ๐ž๐ซ ๐š๐ฅ๐ญ๐ž๐ซ๐ง๐š๐ญ๐ข๐ฏ๐ž๐ฌ ๐ญ๐จ ๐ฌ๐ก๐ข๐ฉ๐ฉ๐ข๐ง๐  ๐จ๐Ÿ๐Ÿ ๐ž๐ฅ๐๐ž๐ซ๐ฅ๐ฒ ๐ฉ๐š๐ซ๐ž๐ง๐ญ๐ฌ ๐ญ๐จ ๐ง๐ฎ๐ซ๐ฌ๐ข๐ง๐  ๐ก๐จ๐ฆ๐ž๐ฌ. Moira Welsh’sย HAPPILY EVER OLDERย is a hopeful investigative work that serves as a “blueprint for change” in long-term careย . Instead of focusing on common horror stories, Welsh travels across North America and Europe to find facilities that have successfully replaced institutional “warehousing” with vibrant […]

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Posted by Michael A. S. Guth on December 19th, 2025

The Institute for Neuroplasticity Research is dedicated to pioneering the next frontier of neurological therapeutics by harnessing the brain’s innate capacity for change. We operate at the critical intersection of advanced science and strategic development, focusing on transformative modalities likeย Cell Replacement Therapyย and novel neuromodulation. Our core mission is to de-risk and accelerate the path of […]

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