“It’s my goal to live to 100 – and it’s not just diet and exercise that will help me achieve it.” — Devi Sridhar Let’s break down the science-backed habits and principles that Devi Sridhar likely incorporates (or advocates for) in her quest to live to 100, beyond just diet and exercise. Many of these […]

Next-Generation Food Fortification: Advances in Nanoencapsulation, Biofortification, and 3D-Printed Functional Foods for Precision Nutrition  Introduction  Context: Global malnutrition challenges and limitations of conventional fortification. Opportunity: Role of novel technologies in addressing bioavailability, sustainability, and personalization. Objective: Review cutting-edge techniques (nanoencapsulation, biofortification, 3D printing) and their synergies for precision nutrition. Global Nutrition Gap: 2 billion people […]

The Many Roads to Healing: How You Can Join the Fight Against Cancer Everyone knows someone. A friend, a parent, a coworker, maybe even yourself—cancer doesn’t care about the boundaries we set. It shows up uninvited, flips life upside down, and forces people into battles they never imagined they’d fight. But here’s the truth that […]

Mitochondrial dysfunction is a key aspect of aging, impacting health and contributing to various age-related diseases. ​ https://urfjournals.org/open-access/mitochondrial-dysfunction-a-hallmark-of-aging-mechanisms-consequences-and-therapeutic-strategies.pdf 1. Introduction Mitochondria are essential for energy production and cellular homeostasis. ​ Aging leads to mitochondrial dysfunction, affecting cellular and systemic health. ​ Mitochondrial dysfunction is linked to neurodegenerative diseases, metabolic disorders, and cardiovascular issues. ​ 2. […]

1. Mechanisms of Stem Cell Exhaustion Telomere Attrition and Replicative Senescence: Studies have shown that telomere shortening in stem cells limits their replicative capacity, leading to senescence or apoptosis. For example, hematopoietic stem cells (HSCs) with critically short telomeres exhibit reduced self-renewal and differentiation potential (Ju et al., Cell Stem Cell, 2007). Telomerase activation has been […]

Dysbiosis, the imbalance in the composition and function of the gut microbiota, is increasingly recognized as a hallmark of aging due to its profound impact on systemic health and its role in age-related diseases. Here’s a detailed explanation of how dysbiosis contributes to aging: Mechanisms Linking Dysbiosis to Aging: Altered Microbial Composition: Reduced Diversity: Aging is […]

Stem cell exhaustion is recognized as a hallmark of aging due to its critical role in impairing tissue regeneration and homeostasis. Here’s a structured explanation of the mechanisms and implications: Key Mechanisms Leading to Stem Cell Exhaustion: Intrinsic Factors: Telomere Attrition: Stem cells have a finite replicative capacity (Hayflick limit). Telomere shortening with each division eventually […]

Enhancing Antibody Therapeutics Through Precision Glycoengineering Antibody therapeutics, particularly monoclonal antibodies (mAbs), have revolutionized the treatment of various diseases, including cancer, autoimmune disorders, and infectious diseases. However, the efficacy of these therapeutics can be significantly influenced by their glycosylation patterns—the addition of sugar moieties to the antibody structure. Precision glycoengineering, the targeted modification of these […]

Aligning quality improvement (QI) measures with the CDC’s 2022 Clinical Practice Guidelines for Prescribing Opioids requires a structured approach to ensure evidence-based practices are implemented effectively. Below is a step-by-step guide to acquiring clinical evidence and providing clinical leadership in this area: 1. Understand the CDC 2022 Opioid Prescribing Guidelines Key Recommendations: Familiarize yourself with the 12 […]

Ocugen’s lead product is OCU400, a gene therapy that treats retinitis pigmentosa (RP) and Leber congenital amaurosis. OCU400 is a modifier gene therapy that aims to improve vision by resetting the retina’s gene network.  How OCU400 works OCU400 delivers a functional copy of the NR2E3 gene to the retina. NR2E3 regulates functions like photoreceptor development, metabolism, and […]