Health insurance coverage in the USA is declining, driven by the expiration of enhanced Affordable Care Act (ACA) subsidies and post-pandemic Medicaid unwinding. Millions are dropping out of the market due to unaffordable premiums, while those who retain plans face narrower networks, stricter coverage denials, and higher out-of-pocket costs. The decline in US health insurance […]

Dear Drs. xxxxxxxxxxxx and xxxxxxxxxxxxxxx, I write to inquire whether the Journal of Clinical Epidemiology would consider a Perspective manuscript entitled xxxxxxxxxxxxxxxxxxxxxxxx. The manuscript (~5,100 words, 37 references) addresses a problem that experienced clinical epidemiologists and HTA reviewers recognize but that the published literature has been reluctant to name directly: when Phase 3 trials produce […]

Adeno-associated virus serotype 9 (AAV9) is highly valued in gene therapy because it can cross the blood-brain barrier. It is primarily used to treat monogenic neurological and neuromuscular disorders, most notably Spinal Muscular Atrophy (SMA). AAV9 vectors deliver functional genetic material to replace or suppress faulty genes. Approved treatments and advanced clinical trials using AAV9 […]

𝐖𝐡𝐲 𝐃𝐍𝐀 𝐎𝐫𝐢𝐠𝐚𝐦𝐢 𝐢𝐬 𝐭𝐡𝐞 𝐒𝐞𝐜𝐫𝐞𝐭 𝐭𝐨 𝐚 “𝐒𝐢𝐥𝐞𝐧𝐭” 𝐕𝐚𝐜𝐜𝐢𝐧𝐞 𝐒𝐜𝐚𝐟𝐟𝐨𝐥𝐝 𝐈𝐧 𝐯𝐚𝐜𝐜𝐢𝐧𝐞 𝐝𝐞𝐬𝐢𝐠𝐧, “𝐨𝐟𝐟-𝐭𝐚𝐫𝐠𝐞𝐭” 𝐫𝐞𝐬𝐩𝐨𝐧𝐬𝐞𝐬 𝐚𝐫𝐞 𝐚 𝐩𝐞𝐫𝐬𝐢𝐬𝐭𝐞𝐧𝐭 𝐡𝐮𝐫𝐝𝐥𝐞. 𝐖𝐡𝐞𝐧 𝐰𝐞 𝐮𝐬𝐞 𝐩𝐫𝐨𝐭𝐞𝐢𝐧-𝐛𝐚𝐬𝐞𝐝 𝐩𝐚𝐫𝐭𝐢𝐜𝐥𝐞𝐬 𝐭𝐨 𝐝𝐞𝐥𝐢𝐯𝐞𝐫 𝐚𝐧 𝐚𝐧𝐭𝐢𝐠𝐞𝐧, 𝐭𝐡𝐞 𝐢𝐦𝐦𝐮𝐧𝐞 𝐬𝐲𝐬𝐭𝐞𝐦 𝐨𝐟𝐭𝐞𝐧 𝐠𝐞𝐭𝐬 𝐝𝐢𝐬𝐭𝐫𝐚𝐜𝐭𝐞𝐝 𝐚𝐧𝐝 𝐚𝐭𝐭𝐚𝐜𝐤𝐬 𝐭𝐡𝐞 𝐝𝐞𝐥𝐢𝐯𝐞𝐫𝐲 𝐯𝐞𝐡𝐢𝐜𝐥𝐞 𝐢𝐭𝐬𝐞𝐥𝐟 𝐢𝐧𝐬𝐭𝐞𝐚𝐝 𝐨𝐟 𝐭𝐡𝐞 𝐯𝐢𝐫𝐮𝐬. 𝐍𝐞𝐰 𝐫𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐟𝐫𝐨𝐦 𝐌𝐈𝐓 𝐚𝐧𝐝 𝐒𝐜𝐫𝐢𝐩𝐩𝐬 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡, 𝐩𝐮𝐛𝐥𝐢𝐬𝐡𝐞𝐝 𝐢𝐧 𝐒𝐜𝐢𝐞𝐧𝐜𝐞, […]

𝗡𝗜𝗖𝗘 𝗥𝗲𝗰𝗼𝗺𝗺𝗲𝗻𝗱𝘀 𝗗𝘂𝗽𝗶𝗹𝘂𝗺𝗮𝗯 𝗳𝗼𝗿 𝗘𝗼𝘀𝗶𝗻𝗼𝗽𝗵𝗶𝗹𝗶𝗰 𝗖𝗢𝗣𝗗: 𝗔 𝗗𝗲𝗲𝗽 𝗗𝗶𝘃𝗲 𝗶𝗻𝘁𝗼 𝘁𝗵𝗲 𝗘𝘃𝗶𝗱𝗲𝗻𝗰𝗲 𝗮𝗻𝗱 𝗘𝗰𝗼𝗻𝗼𝗺𝗶𝗰 𝗖𝗮𝘀𝗲 𝗧𝗵𝗲 𝗨𝗞’𝘀 𝗡𝗮𝘁𝗶𝗼𝗻𝗮𝗹 𝗜𝗻𝘀𝘁𝗶𝘁𝘂𝘁𝗲 𝗳𝗼𝗿 𝗛𝗲𝗮𝗹𝘁𝗵 𝗮𝗻𝗱 𝗖𝗮𝗿𝗲 𝗘𝘅𝗰𝗲𝗹𝗹𝗲𝗻𝗰𝗲 (𝗡𝗜𝗖𝗘) 𝗵𝗮𝘀 𝗶𝘀𝘀𝘂𝗲𝗱 𝗳𝗶𝗻𝗮𝗹 𝗱𝗿𝗮𝗳𝘁 𝗴𝘂𝗶𝗱𝗮𝗻𝗰𝗲 𝗿𝗲𝗰𝗼𝗺𝗺𝗲𝗻𝗱𝗶𝗻𝗴 𝗱𝘂𝗽𝗶𝗹𝘂𝗺𝗮𝗯 𝗮𝘀 𝗮𝗻 𝗮𝗱𝗱-𝗼𝗻 𝗺𝗮𝗶𝗻𝘁𝗲𝗻𝗮𝗻𝗰𝗲 𝘁𝗵𝗲𝗿𝗮𝗽𝘆 𝗳𝗼𝗿 𝗮 𝘀𝗽𝗲𝗰𝗶𝗳𝗶𝗰, 𝗵𝗶𝗴𝗵-𝗻𝗲𝗲𝗱 𝗖𝗢𝗣𝗗 𝗽𝗼𝗽𝘂𝗹𝗮𝘁𝗶𝗼𝗻. 𝗧𝗵𝗶𝘀 𝗺𝗮𝗿𝗸𝘀 𝗮 𝗽𝗶𝘃𝗼𝘁𝗮𝗹 𝘀𝗵𝗶𝗳𝘁 𝘁𝗼𝘄𝗮𝗿𝗱𝘀 𝗽𝗿𝗲𝗰𝗶𝘀𝗶𝗼𝗻 𝗺𝗲𝗱𝗶𝗰𝗶𝗻𝗲 𝗶𝗻 𝗰𝗵𝗿𝗼𝗻𝗶𝗰 𝗿𝗲𝘀𝗽𝗶𝗿𝗮𝘁𝗼𝗿𝘆 𝗱𝗶𝘀𝗲𝗮𝘀𝗲. […]