While Aβ patrols the extracellular space, the microtubule-associated protein tau functions within neurons. In its normal state, tau stabilizes micro-tubules, which are crucial for axonal transport and structural integrity. Its pathological transformation into hyperphosphorylated, aggregated NFTs is another diagnostic hallmark of AD and strongly correlates with cognitive decline (Jellinger, 2020). The DSH suggests viewing pathological […]