DSH vs. Biogen Diranersen Phase 2 (Celia study) — Compatibility Assessment Bottom line: The Celia results do not constitute counter-evidence to DSH. They’re compatible with its core claim about therapeutic ceilings, but nothing in the trial tests DSH’s actual falsifiable content (nanoplastic nucleation, glymphatic obstruction, NLRP3/pyroptosis, NP-tangle colocalization). Log this as consistent-with, not confirmatory-of. 1. […]
Archive for July 14th, 2026
Do the Biogen Diranersen Phase 2 (Celia study) results provide counter-evidence to my Dual Sequestration Hypothesis?
Posted by Michael A. S. Guth on July 14th, 2026
Posted in 
Resistance Training and Neuroplasticity
Posted by Michael A. S. Guth on July 14th, 2026
Recent research (Vints et al., 2024, GeroScience) offers critical insights into the biological underpinnings of how resistance training influences the aging brain. By utilizing a randomized controlled trial design, the study examined 70 older adults (aged 60–85) stratified by MCI risk via MoCA scores, shedding light on the structural and neurochemical shifts induced by a […]