𝐈𝐧 𝐨𝐮𝐫 𝐃𝐮𝐚𝐥 𝐒𝐞𝐪𝐮𝐞𝐬𝐭𝐫𝐚𝐭𝐢𝐨𝐧 𝐇𝐲𝐩𝐨𝐭𝐡𝐞𝐬𝐢𝐬 𝐟𝐨𝐫 𝐀𝐥𝐳𝐡𝐞𝐢𝐦𝐞𝐫’𝐬 𝐝𝐢𝐬𝐞𝐚𝐬𝐞: 𝐓𝐡𝐞 𝐞𝐱𝐭𝐫𝐚𝐜𝐞𝐥𝐥𝐮𝐥𝐚𝐫 𝐬𝐚𝐫𝐜𝐨𝐩𝐡𝐚𝐠𝐮𝐬: 𝐚𝐦𝐲𝐥𝐨𝐢𝐝-β  We suggest reframing the Aβ plaque not as a pathogenic endpoint but as an extracellular sarcophagus—a first-responder mechanism that sequesters insoluble or toxic material in the interstitial space. This view is supported by substantial evidence challenging Aβ’s role as merely metabolic waste. From […]