The Dual Sequestration Hypothesis as a Clinicopathological Synthesis We propose the DSH as a unifying framework to resolve these converging crises. This clinicopathological update posits that sporadic Alzheimer’s disease, particularly in its modern manifestation, could be understood as a disease of maladaptive innate immunity. The DSH suggests reframing Aβ and tau pathologies not as intrinsic pathogens […]

𝐓𝐡𝐞 𝐌𝐢𝐜𝐫𝐨𝐩𝐥𝐚𝐬𝐭𝐢𝐜 𝐓𝐡𝐫𝐞𝐚𝐭 𝐀𝐜𝐜𝐞𝐥𝐞𝐫𝐚𝐭𝐢𝐧𝐠 𝐀𝐥𝐳𝐡𝐞𝐢𝐦𝐞𝐫’𝐬 𝐃𝐢𝐬𝐞𝐚𝐬𝐞 Parallel to this clinical quandary, environmental science has uncovered a novel, pervasive threat to neural integrity. Micro- and nanoplastics, ubiquitous contaminants of the Anthropocene, have infiltrated global ecosystems and, consequently, the human body. These synthetic polymer particles have been confirmed to breach critical biological barriers and have been detected […]