Niacinamide is currently one of the most celebrated ingredients in skincare, praised in every beauty and wellness journal for its ability to strengthen the skin barrier topically. But lately, there has been a lot of buzz about taking it orally to prevent skin cancer. Does the science back up the hype? Yes—but with some major […]

Real-World Evidence vs. Meta-Analyses: The Evolving Debate on Nicotinamide for Skin Cancer Chemoprevention The clinical utility of oral nicotinamide (NAM) for non-melanoma skin cancer (NMSC) chemoprevention remains a prime example of the tension between landmark RCT data, real-world evidence (RWE), and systematic evidence syntheses. While the 2015 Phase 3 ONTRAC trial established a 23% reduction […]