𝐈𝐬 𝐓𝐃𝐏-𝟒𝟑 𝐭𝐡𝐞 𝐥𝐲𝐧𝐜𝐡𝐩𝐢𝐧 𝐟𝐨𝐫 𝐟𝐢𝐧𝐝𝐢𝐧𝐠 𝐭𝐫𝐞𝐚𝐭𝐦𝐞𝐧𝐭 𝐟𝐨𝐫 𝐀𝐋𝐒? Two pathologies, one protein The field has increasingly recognized that TDP-43 dysfunction operates through two parallel mechanisms. The cytoplasmic gain-of-function toxicity that CTx1000 directly targets is only half the story. Equally consequential is the loss of normal nuclear TDP-43 function, particularly its role in RNA splicing […]