https://authors.elsevier.com/a/1nYxN4r9Rkz1wZ TDP-43 is the most common neuropathological signature of ALS and one of the two most common pathologies in frontotemporal dementia (FTD), alongside fused in sarcoma (FUS) proteinopathy.10,11 Its cytoplasmic mislocalization and aggregation are observed in approximately 97% of all ALS cases, both sporadic and familial, with the notable exceptions of SOD1-linked disease and FUS-associated […]