Abstract
Nicotinamide riboside (NR), a precursor to nicotinamide adenine dinucleotide (NAD+), has emerged as a popular anti-aging supplement due to its role in cellular energy metabolism and sirtuin activation. Preclinical studies in model organisms demonstrate that NR supplementation can counteract age-related NAD+ decline, improving mitochondrial function, reducing inflammation, and extending lifespan. However, human clinical trials reveal only modest benefits—such as enhanced muscle endurance and mild cardiometabolic improvements—with limitations including short study durations, small sample sizes, and potential industry bias. While NR appears safe at doses up to 2,000 mg/day, concerns persist about its long-term effects and overstated commercial claims. This review critically evaluates the translational gap between animal data and human outcomes, emphasizing the need for rigorous, independent research to validate NR’s anti-aging potential.
Keyword Phrases
- Nicotinamide riboside (NR) supplementation
- NAD+ decline and aging
- NR clinical trials evidence
- Anti-aging supplements hype vs. science
- NAD+ boosters and longevity
Optional sidebar comment
While NR shows promise in countering age-related NAD+ decline, robust human evidence is lacking. Current data support mild metabolic benefits, but exaggerated claims outpace clinical validation. Long-term, randomized trials are needed to assess NR’s true anti-aging potential.
https://crimsonpublishers.com/ntnf/pdf/NTNF.000692.pdf
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