๐๐๐ฐ ๐๐ฎ๐๐ฅ๐ข๐๐๐ญ๐ข๐จ๐ง ๐ข๐ง ๐ ๐ซ๐๐ ๐๐๐ฎ๐ซ๐จ๐ฉ๐๐ญ๐ก๐จ๐ฅ๐จ๐ ๐ฒ (๐๐ฎ๐ง๐ ๐๐๐๐) ๐ ๐๐ฆ ๐ฉ๐ฅ๐๐๐ฌ๐๐ ๐ญ๐จ ๐ฌ๐ก๐๐ซ๐ ๐จ๐ฎ๐ซ ๐ฅ๐๐ญ๐๐ฌ๐ญ ๐๐ฅ๐ข๐ง๐ข๐๐จ๐ฉ๐๐ญ๐ก๐จ๐ฅ๐จ๐ ๐ข๐๐๐ฅ ๐ฎ๐ฉ๐๐๐ญ๐ ๐๐๐๐ซ๐๐ฌ๐ฌ๐ข๐ง๐ ๐ ๐ฉ๐๐ซ๐ฌ๐ข๐ฌ๐ญ๐๐ง๐ญ ๐ฉ๐๐ซ๐๐๐จ๐ฑ ๐ข๐ง ๐๐ฅ๐ณ๐ก๐๐ข๐ฆ๐๐ซ’๐ฌ ๐๐ข๐ฌ๐๐๐ฌ๐: ๐ฐ๐ก๐ฒ ๐ญ๐ก๐๐ซ๐๐ฉ๐ข๐๐ฌ ๐ญ๐๐ซ๐ ๐๐ญ๐ข๐ง๐ ๐ญ๐ก๐ ๐ซ๐๐ฆ๐จ๐ฏ๐๐ฅ ๐จ๐ ๐๐ฆ๐ฒ๐ฅ๐จ๐ข๐-ฮฒ ๐ฉ๐ฅ๐๐ช๐ฎ๐๐ฌ ๐๐ง๐ ๐ญ๐๐ฎ ๐ญ๐๐ง๐ ๐ฅ๐๐ฌ ๐๐จ๐ง๐ฌ๐ข๐ฌ๐ญ๐๐ง๐ญ๐ฅ๐ฒ ๐ฌ๐ก๐จ๐ฐ ๐ ๐๐ซ๐ข๐ญ๐ข๐๐๐ฅ ๐๐ข๐ฌ๐ฌ๐จ๐๐ข๐๐ญ๐ข๐จ๐ง ๐๐ซ๐จ๐ฆ ๐๐จ๐ซ๐ ๐๐ฅ๐ข๐ง๐ข๐๐๐ฅ ๐ฉ๐๐ญ๐ก๐จ๐ ๐๐ง๐๐ฌ๐ข๐ฌ. ๐๐ง “๐๐ฅ๐ณ๐ก๐๐ข๐ฆ๐๐ซ’๐ฌ ๐๐ข๐ฌ๐๐๐ฌ๐ ๐ข๐ง ๐ญ๐ก๐ ๐๐ฅ๐๐ฌ๐ญ๐ข๐๐๐ง๐ ๐๐ซ๐: ๐ ๐๐ฅ๐ข๐ง๐ข๐๐จ๐ฉ๐๐ญ๐ก๐จ๐ฅ๐จ๐ ๐ข๐๐๐ฅ ๐ฎ๐ฉ๐๐๐ญ๐ ๐จ๐ง ๐ญ๐ก๐ […]
Archive for the ‘Neuroplasticity’ Category
Alzheimer’s Dual Sequestration Hypothesis
Posted in About, Neuroplasticity, Pharma and Medical Device, Regulatory Medical Writing 
Comments Off on Alzheimer’s Dual Sequestration HypothesisDiffuse Lewy Body Dementia in the Great Robin Williams
I have the deepest, most profound respect for Robin Williams. I wish it were more widely known, while he was still living, what a decent, caring, sympathetic person Robin Williams was. I just finished watching the documentary โRobinโs Wishโ (available to stream on Plex and Tubi) and learned that the cause of death in the […]
๐๐ก๐๐ญ ๐๐ซ๐ ๐ญ๐ก๐ ๐ฆ๐จ๐ฌ๐ญ ๐ก๐๐ซ๐ฆ๐๐ฎ๐ฅ ๐๐จ๐จ๐ ๐ข๐ง๐ ๐ซ๐๐๐ข๐๐ง๐ญ๐ฌ ๐ญ๐ก๐๐ญ ๐๐จ๐ง๐ญ๐ซ๐ข๐๐ฎ๐ญ๐ ๐ญ๐จ ๐๐๐ฆ๐๐ง๐ญ๐ข๐ ๐ซ๐ข๐ฌ๐ค?
The most harmful industrial ingredients contributing to dementia risk are processed meat preservatives (nitrites/nitrates), added sugars (high-fructose corn syrup), and chemical additives like emulsifiers. Rather than focusing on a single nutrient, public health studiesโincluding recent 2026 data from the Harvard T.H. Chan School of Public Healthโpoint to specific chemical formulations and industrial ingredients that directly […]
Posted in Neuroplasticity, Regulatory Medical Writing Comments Off on ๐๐ก๐๐ญ ๐๐ซ๐ ๐ญ๐ก๐ ๐ฆ๐จ๐ฌ๐ญ ๐ก๐๐ซ๐ฆ๐๐ฎ๐ฅ ๐๐จ๐จ๐ ๐ข๐ง๐ ๐ซ๐๐๐ข๐๐ง๐ญ๐ฌ ๐ญ๐ก๐๐ญ ๐๐จ๐ง๐ญ๐ซ๐ข๐๐ฎ๐ญ๐ ๐ญ๐จ ๐๐๐ฆ๐๐ง๐ญ๐ข๐ ๐ซ๐ข๐ฌ๐ค?National Alzheimer’s Prevention Policy
“๐๐ฎ๐๐ ๐ ๐ ๐ฆ๐๐ง ๐๐ฒ ๐ก๐ข๐ฌ ๐ช๐ฎ๐๐ฌ๐ญ๐ข๐จ๐ง๐ฌ ๐ซ๐๐ญ๐ก๐๐ซ ๐ญ๐ก๐๐ง ๐๐ฒ ๐ก๐ข๐ฌ ๐๐ง๐ฌ๐ฐ๐๐ซ๐ฌ.” – ๐๐จ๐ฅ๐ญ๐๐ข๐ซ๐ย ย ย So hereโs my question: Should a national policy treat perfectly healthy, โat riskโ people for Alzheimerโs before they show a single symptom? Iโve spent the last several months researching and writing exactly that โ a new national prophylaxis framework for Alzheimerโs […]
Accelerating the Orphan GPCR Pipeline: GPR149 as a Case Study in Dual-Domain Target Validation
https://doi.org/10.1016/j.drudis.2026.104678ย Free download of the article using this link until June 16:ย https://authors.elsevier.com/a/1n0uP4r9Rkz1l6 Highlights New four-pillar framework accelerates deorphanization of dark GPCR targets. (77 chars) GPR149 structural analysis identifies non-canonical ERY and DPxxF motifs. (76 chars) Path-agnostic screening bypasses traditional Gi/oย signaling limitations. (75 chars) Integrated CNS and metabolic mapping reveals GPR149โฒs dual-domain value. (76 chars) […]
Posted in About, Featured, Neuroplasticity Comments Off on Accelerating the Orphan GPCR Pipeline: GPR149 as a Case Study in Dual-Domain Target ValidationThe Future of PTSD Treatment: Beyond the Daily Pill
We are currently witnessing a “Neuroplasticity Revolution” that is redefining the landscape of mental health care. Traditional treatments have often focused on managing the symptoms of PTSD through daily medication, but the focus is now shifting toward remodeling the brain’s actual architecture. This approach aims to fix the “hardware” of the brain, rather than just […]
Posted in Neuroplasticity, Pharma and Medical Device Comments Off on The Future of PTSD Treatment: Beyond the Daily Pill๐๐๐๐๐ฅ๐ข๐ง๐: ๐๐๐ฒ๐จ๐ง๐ ๐๐ฒ๐ง๐๐ฉ๐ฌ๐๐ฌ: ๐๐ก๐ ๐๐จ๐ฅ๐ ๐จ๐ ๐๐ฒ๐๐ฅ๐ข๐ง ๐๐ฅ๐๐ฌ๐ญ๐ข๐๐ข๐ญ๐ฒ ๐๐ง๐ ๐๐๐ฎ๐ซ๐จ๐ญ๐ซ๐จ๐ฉ๐ก๐ข๐ ๐๐ข๐ ๐ง๐๐ฅ๐ข๐ง๐ ๐ข๐ง ๐๐๐๐ ๐๐๐ญ๐ก๐จ๐ฉ๐ก๐ฒ๐ฌ๐ข๐จ๐ฅ๐จ๐ ๐ฒ
Recent evidence published in Revista de Neurologรญa highlights a critical shift in our understanding of Post-Traumatic Stress Disorder (PTSD). While traditional models focus heavily on synaptic weakening, new data underscores the sophisticated role of myelin plasticity within the amygdala-hippocampus-prefrontal cortex (PFC) circuit. This remodeling is not merely a byproduct of trauma but a fundamental mechanism […]
Posted in Neuroplasticity Comments Off on ๐๐๐๐๐ฅ๐ข๐ง๐: ๐๐๐ฒ๐จ๐ง๐ ๐๐ฒ๐ง๐๐ฉ๐ฌ๐๐ฌ: ๐๐ก๐ ๐๐จ๐ฅ๐ ๐จ๐ ๐๐ฒ๐๐ฅ๐ข๐ง ๐๐ฅ๐๐ฌ๐ญ๐ข๐๐ข๐ญ๐ฒ ๐๐ง๐ ๐๐๐ฎ๐ซ๐จ๐ญ๐ซ๐จ๐ฉ๐ก๐ข๐ ๐๐ข๐ ๐ง๐๐ฅ๐ข๐ง๐ ๐ข๐ง ๐๐๐๐ ๐๐๐ญ๐ก๐จ๐ฉ๐ก๐ฒ๐ฌ๐ข๐จ๐ฅ๐จ๐ ๐ฒIn the 1950s, my physicist father met with Albert Einstein at the Institute for Advanced Study to discuss unified field theory.
In the 1950s, my physicist father, Eugene Guth, met with Albert Einstein at the Institute for Advanced Study to discuss unified field theory. Einstein, it turned out, was more interested in the philosophy of physics than the math, a topic equally of interest to my dad.ย See https://michaelguth.com/family/HistoryofPhysicsbyEugeneGuth.htm Mathematics and philosophy of physics have relevance […]
Posted in About, Featured, Neuroplasticity, Pharma and Medical Device Comments Off on In the 1950s, my physicist father met with Albert Einstein at the Institute for Advanced Study to discuss unified field theory.Eden Alternativeย and theย Butterfly Model Instead of Nursing Home Care
Both theย Eden Alternativeย and theย Butterfly Modelย are philosophies of care that seek to radically transform the traditional, institutional nursing home into a vibrant, person-centered home. Moira Welsh features both inย Happily Ever Olderย as leading examples of successful, humane care modelsย . While they share the same goal of eliminating loneliness, helplessness, and boredom, their origins and methods differ. Hereโs […]
Posted in Neuroplasticity Comments Off on Eden Alternativeย and theย Butterfly Model Instead of Nursing Home CareA New Blueprint for Turning an Orphan Brain Receptor into a Blockbuster Drug Target
Forthcoming inย Drug Discovery Today: A New Blueprint for Turning an Orphan Brain Receptor into a Blockbuster Drug Target I am pleased to announce that my article, “Accelerating the Orphan GPCR Pipeline: GPR149 as a Case Study in Dual-Domain Target Validation,” has been accepted for publication inย Drug Discovery Today, a leading journal for pharmaceutical strategy and […]
Posted in Neuroplasticity, Pharma and Medical Device Comments Off on A New Blueprint for Turning an Orphan Brain Receptor into a Blockbuster Drug Target