DSH vs. Biogen Diranersen Phase 2 (Celia study) โ Compatibility Assessment Bottom line: The Celia results do not constitute counter-evidence to DSH. They’re compatible with its core claim about therapeutic ceilings, but nothing in the trial tests DSH’s actual falsifiable content (nanoplastic nucleation, glymphatic obstruction, NLRP3/pyroptosis, NP-tangle colocalization). Log this as consistent-with, not confirmatory-of. 1. […]
Archive for the ‘Neuroplasticity’ Category
Do the Biogen Diranersen Phase 2 (Celia study) results provide counter-evidence to my Dual Sequestration Hypothesis?
Posted by Michael A. S. Guth on July 14th, 2026
Posted in Neuroplasticity, Pharma and Medical Device, Regulatory Medical Writing 
Comments Off on Do the Biogen Diranersen Phase 2 (Celia study) results provide counter-evidence to my Dual Sequestration Hypothesis?Resistance Training and Neuroplasticity
Posted by Michael A. S. Guth on July 14th, 2026
Recent research (Vints et al., 2024, GeroScience) offers critical insights into the biological underpinnings of how resistance training influences the aging brain. By utilizing a randomized controlled trial design, the study examined 70 older adults (aged 60โ85) stratified by MCI risk via MoCA scores, shedding light on the structural and neurochemical shifts induced by a […]
๐๐ก๐ ๐ก๐ข๐ฌ๐ญ๐จ๐ซ๐ข๐๐๐ฅ ๐ ๐ซ๐๐๐ข๐๐ง๐ญ ๐จ๐ ๐๐ฅ๐ณ๐ก๐๐ข๐ฆ๐๐ซ’๐ฌ ๐ญ๐ซ๐ข๐ ๐ ๐๐ซ๐ฌ
Posted by Michael A. S. Guth on July 13th, 2026
๐๐ก๐ ๐ก๐ข๐ฌ๐ญ๐จ๐ซ๐ข๐๐๐ฅ ๐ ๐ซ๐๐๐ข๐๐ง๐ญ ๐จ๐ ๐๐ฅ๐ณ๐ก๐๐ข๐ฆ๐๐ซ’๐ฌ ๐ญ๐ซ๐ข๐ ๐ ๐๐ซ๐ฌย from industrial contaminants to theย Plasticene A complete understanding of the Dual Sequestration Hypothesisย requires situating the Plasticeneย trigger within a broader historical timeline of escalating environmental neural incursion. AD was not absent before the modern eraโhistorical cases existโbut its incidence has risen dramatically over the past century in a pattern that cannot […]
Posted in Aging Adults, Neuroplasticity, Regulatory Medical Writing Comments Off on ๐๐ก๐ ๐ก๐ข๐ฌ๐ญ๐จ๐ซ๐ข๐๐๐ฅ ๐ ๐ซ๐๐๐ข๐๐ง๐ญ ๐จ๐ ๐๐ฅ๐ณ๐ก๐๐ข๐ฆ๐๐ซ’๐ฌ ๐ญ๐ซ๐ข๐ ๐ ๐๐ซ๐ฌThe Minority View of Aฮฒ in Alzheimer’s Disease is gaining ground on the Established View
Posted by Michael A. S. Guth on July 9th, 2026
We propose the DSH as a unifying framework to resolve these converging crises. This clinicopathological update posits that sporadic AD, particularly in its modern manifestation, could be understood as a disease of maladaptive innate immunity. The DSH suggests reframing Aฮฒ and tau pathologies not as intrinsic pathogens but as visible remnants of overwhelmed, evolutionarily conserved […]
Posted in Aging Adults, Neuroplasticity, Pharma and Medical Device, Regulatory Medical Writing Comments Off on The Minority View of Aฮฒ in Alzheimer’s Disease is gaining ground on the Established ViewThe Hidden Gatekeeper: A Serial Killer Inside the Human Brain
Posted by Michael A. S. Guth on June 29th, 2026
The Hidden Gatekeeperย Best for an engaging, true-crime-style narrative that builds suspense paragraph by paragraph. For over thirty years, neurologists have been tracking a serial killer inside the human brain. We call its wake Alzheimerโs disease. When scientists look at the brains of those affected, they always find the same gruesome crime scene: millions of vital […]
Posted in Neuroplasticity, Pharma and Medical Device Comments Off on The Hidden Gatekeeper: A Serial Killer Inside the Human BrainThe choroid plexus (ChP): hydrodynamic bottleneck and ground zero for Alzheimer’s
Posted by Michael A. S. Guth on June 29th, 2026
The choroid plexus (ChP): hydrodynamic bottleneck and ground zero for Alzheimer’s diseaseย https://ejournals.uni-muenster.de/fnp/article/view/9368/9664 The Institute has advanced a Dual Sequestration Hypothesis (DSH) related to the protein signatures prevalent in Alzheimer’s disease.ย If the DSH is correct, the ChP should enlarge and become the sentinel hydrodynamic bottleneck as synthetic particles and their protein sequestrants accumulate. This […]
Posted in Featured, Neuroplasticity, Pharma and Medical Device Comments Off on The choroid plexus (ChP): hydrodynamic bottleneck and ground zero for Alzheimer’s๐ช๐ฒ ๐ฎ๐น๐ฟ๐ฒ๐ฎ๐ฑ๐ ๐ธ๐ป๐ผ๐ ๐บ๐ถ๐ฐ๐ฟ๐ผ๐ฝ๐น๐ฎ๐๐๐ถ๐ฐ๐ ๐ฎ๐ฟ๐ฒ ๐ถ๐ป ๐ผ๐๐ฟ ๐๐ฎ๐๐ฒ๐ฟ, ๐ผ๐๐ฟ ๐ณ๐ผ๐ผ๐ฑ, ๐ฎ๐ป๐ฑ ๐ผ๐๐ฟ ๐ผ๐ฐ๐ฒ๐ฎ๐ป๐. ๐๐๐ ๐๐ต๐ฎ๐ ๐ต๐ฎ๐ฝ๐ฝ๐ฒ๐ป๐ ๐๐ต๐ฒ๐ป ๐๐ต๐ฒ๐ ๐ฟ๐ฒ๐ฎ๐ฐ๐ต ๐๐ต๐ฒ ๐ต๐๐บ๐ฎ๐ป ๐ฏ๐ฟ๐ฎ๐ถ๐ป?
Posted by Michael A. S. Guth on June 25th, 2026
๐๐ฒ๐๐ ๐ณ๐ผ๐ฟ: ๐๐ถ๐ด๐ต ๐ฒ๐ป๐ด๐ฎ๐ด๐ฒ๐บ๐ฒ๐ป๐ ๐ฎ๐ป๐ฑ ๐๐ต๐ฎ๐ฟ๐ฒ๐ฎ๐ฏ๐ถ๐น๐ถ๐๐. ๐๐ ๐ฐ๐ผ๐ป๐ป๐ฒ๐ฐ๐๐ ๐ฎ ๐ฑ๐ฒ๐ฒ๐ฝ๐น๐ ๐๐ฒ๐ฐ๐ต๐ป๐ถ๐ฐ๐ฎ๐น ๐ฝ๐ฎ๐ฝ๐ฒ๐ฟ ๐๐ผ ๐ฎ ๐บ๐ฎ๐๐๐ถ๐๐ฒ, ๐ฟ๐ฒ๐ฎ๐น-๐๐ผ๐ฟ๐น๐ฑ ๐ถ๐๐๐๐ฒ ๐๐ต๐ฎ๐ ๐ฒ๐๐ฒ๐ฟ๐ ๐ฝ๐ฟ๐ผ๐ณ๐ฒ๐๐๐ถ๐ผ๐ป๐ฎ๐น ๐ผ๐ป ๐๐ถ๐ป๐ธ๐ฒ๐ฑ๐๐ป ๐ฐ๐ฎ๐ป ๐ฟ๐ฒ๐น๐ฎ๐๐ฒ ๐๐ผ: ๐ฝ๐น๐ฎ๐๐๐ถ๐ฐ ๐ฝ๐ผ๐น๐น๐๐๐ถ๐ผ๐ป ๐ฎ๐ป๐ฑ ๐ต๐๐บ๐ฎ๐ป ๐ต๐ฒ๐ฎ๐น๐๐ต. ๐ช๐ฒ ๐ฎ๐ฟ๐ฒ ๐น๐ถ๐๐ถ๐ป๐ด ๐ถ๐ป ๐๐ต๐ฒ “๐ฃ๐น๐ฎ๐๐๐ถ๐ฐ๐ฒ๐ป๐ฒ” ๐ฒ๐ฟ๐ฎโ๐ฎ๐ป๐ฑ ๐ถ๐ ๐บ๐ถ๐ด๐ต๐ ๐ฏ๐ฒ ๐ฎ๐น๐๐ฒ๐ฟ๐ถ๐ป๐ด ๐ต๐ผ๐ ๐๐ฒ ๐๐ต๐ถ๐ป๐ธ ๐ฎ๐ฏ๐ผ๐๐ ๐ฏ๐ฟ๐ฎ๐ถ๐ป ๐ต๐ฒ๐ฎ๐น๐๐ต. ๐ช๐ฒ ๐ฎ๐น๐ฟ๐ฒ๐ฎ๐ฑ๐ ๐ธ๐ป๐ผ๐ ๐บ๐ถ๐ฐ๐ฟ๐ผ๐ฝ๐น๐ฎ๐๐๐ถ๐ฐ๐ ๐ฎ๐ฟ๐ฒ ๐ถ๐ป ๐ผ๐๐ฟ ๐๐ฎ๐๐ฒ๐ฟ, […]
Posted in Neuroplasticity, Pharma and Medical Device, Regulatory Medical Writing Comments Off on ๐ช๐ฒ ๐ฎ๐น๐ฟ๐ฒ๐ฎ๐ฑ๐ ๐ธ๐ป๐ผ๐ ๐บ๐ถ๐ฐ๐ฟ๐ผ๐ฝ๐น๐ฎ๐๐๐ถ๐ฐ๐ ๐ฎ๐ฟ๐ฒ ๐ถ๐ป ๐ผ๐๐ฟ ๐๐ฎ๐๐ฒ๐ฟ, ๐ผ๐๐ฟ ๐ณ๐ผ๐ผ๐ฑ, ๐ฎ๐ป๐ฑ ๐ผ๐๐ฟ ๐ผ๐ฐ๐ฒ๐ฎ๐ป๐. ๐๐๐ ๐๐ต๐ฎ๐ ๐ต๐ฎ๐ฝ๐ฝ๐ฒ๐ป๐ ๐๐ต๐ฒ๐ป ๐๐ต๐ฒ๐ ๐ฟ๐ฒ๐ฎ๐ฐ๐ต ๐๐ต๐ฒ ๐ต๐๐บ๐ฎ๐ป ๐ฏ๐ฟ๐ฎ๐ถ๐ป?“๐๐ป๐๐ฎ๐ป๐ถ๐๐ ๐ถ๐ ๐ฑ๐ผ๐ถ๐ป๐ด ๐๐ต๐ฒ ๐๐ฎ๐บ๐ฒ ๐๐ต๐ถ๐ป๐ด ๐ผ๐๐ฒ๐ฟ ๐ฎ๐ป๐ฑ ๐ผ๐๐ฒ๐ฟ ๐ฎ๐ด๐ฎ๐ถ๐ป ๐ฎ๐ป๐ฑ ๐ฒ๐ ๐ฝ๐ฒ๐ฐ๐๐ถ๐ป๐ด ๐ฑ๐ถ๐ณ๐ณ๐ฒ๐ฟ๐ฒ๐ป๐ ๐ฟ๐ฒ๐๐๐น๐๐.” Alzheimer’s disease research!
Posted by Michael A. S. Guth on June 25th, 2026
“๐๐ป๐๐ฎ๐ป๐ถ๐๐ ๐ถ๐ ๐ฑ๐ผ๐ถ๐ป๐ด ๐๐ต๐ฒ ๐๐ฎ๐บ๐ฒ ๐๐ต๐ถ๐ป๐ด ๐ผ๐๐ฒ๐ฟ ๐ฎ๐ป๐ฑ ๐ผ๐๐ฒ๐ฟ ๐ฎ๐ด๐ฎ๐ถ๐ป ๐ฎ๐ป๐ฑ ๐ฒ๐ ๐ฝ๐ฒ๐ฐ๐๐ถ๐ป๐ด ๐ฑ๐ถ๐ณ๐ณ๐ฒ๐ฟ๐ฒ๐ป๐ ๐ฟ๐ฒ๐๐๐น๐๐.” ๐๐ผ๐ฟ ๐ฑ๐ฒ๐ฐ๐ฎ๐ฑ๐ฒ๐, ๐๐ต๐ฒ ๐ฏ๐ถ๐ผ๐๐ฒ๐ฐ๐ต ๐ถ๐ป๐ฑ๐๐๐๐ฟ๐ ๐ต๐ฎ๐ ๐ฝ๐ผ๐๐ฟ๐ฒ๐ฑ ๐ฏ๐ถ๐น๐น๐ถ๐ผ๐ป๐ ๐ถ๐ป๐๐ผ ๐ฎ ๐๐ถ๐ป๐ด๐๐น๐ฎ๐ฟ ๐ด๐ผ๐ฎ๐น ๐ณ๐ผ๐ฟ ๐๐น๐๐ต๐ฒ๐ถ๐บ๐ฒ๐ฟโ๐ ๐ฑ๐ถ๐๐ฒ๐ฎ๐๐ฒ: ๐ฐ๐น๐ฒ๐ฎ๐ฟ๐ถ๐ป๐ด ๐ฎ๐บ๐๐น๐ผ๐ถ๐ฑ ๐ฝ๐น๐ฎ๐พ๐๐ฒ๐ ๐ฎ๐ป๐ฑ ๐๐ฎ๐ ๐๐ฎ๐ป๐ด๐น๐ฒ๐ ๐ณ๐ฟ๐ผ๐บ ๐๐ต๐ฒ ๐ฏ๐ฟ๐ฎ๐ถ๐ป. ๐ฌ๐ฒ๐, ๐ฐ๐น๐ถ๐ป๐ถ๐ฐ๐ฎ๐น ๐๐ฟ๐ถ๐ฎ๐น ๐ฎ๐ณ๐๐ฒ๐ฟ ๐ฐ๐น๐ถ๐ป๐ถ๐ฐ๐ฎ๐น ๐๐ฟ๐ถ๐ฎ๐น ๐ต๐ฎ๐ ๐ณ๐ฎ๐ฐ๐ฒ๐ฑ ๐ฑ๐ถ๐๐ฎ๐ฝ๐ฝ๐ผ๐ถ๐ป๐๐ถ๐ป๐ด ๐ณ๐ฎ๐ถ๐น๐๐ฟ๐ฒ๐. ๐ง๐ต๐ฒ ๐ฝ๐น๐ฎ๐พ๐๐ฒ๐ ๐ฎ๐ฟ๐ฒ ๐ฟ๐ฒ๐บ๐ผ๐๐ฒ๐ฑ, ๐ฏ๐๐ ๐๐ต๐ฒ ๐ฐ๐ผ๐ด๐ป๐ถ๐๐ถ๐๐ฒ […]
Posted in Neuroplasticity, Pharma and Medical Device, Regulatory Medical Writing Comments Off on “๐๐ป๐๐ฎ๐ป๐ถ๐๐ ๐ถ๐ ๐ฑ๐ผ๐ถ๐ป๐ด ๐๐ต๐ฒ ๐๐ฎ๐บ๐ฒ ๐๐ต๐ถ๐ป๐ด ๐ผ๐๐ฒ๐ฟ ๐ฎ๐ป๐ฑ ๐ผ๐๐ฒ๐ฟ ๐ฎ๐ด๐ฎ๐ถ๐ป ๐ฎ๐ป๐ฑ ๐ฒ๐
๐ฝ๐ฒ๐ฐ๐๐ถ๐ป๐ด ๐ฑ๐ถ๐ณ๐ณ๐ฒ๐ฟ๐ฒ๐ป๐ ๐ฟ๐ฒ๐๐๐น๐๐.” Alzheimer’s disease research!Alzheimer’s Dual Sequestration Hypothesis
Posted by Michael A. S. Guth on June 25th, 2026
๐๐๐ฐ ๐๐ฎ๐๐ฅ๐ข๐๐๐ญ๐ข๐จ๐ง ๐ข๐ง ๐ ๐ซ๐๐ ๐๐๐ฎ๐ซ๐จ๐ฉ๐๐ญ๐ก๐จ๐ฅ๐จ๐ ๐ฒ (๐๐ฎ๐ง๐ ๐๐๐๐) ๐ ๐๐ฆ ๐ฉ๐ฅ๐๐๐ฌ๐๐ ๐ญ๐จ ๐ฌ๐ก๐๐ซ๐ ๐จ๐ฎ๐ซ ๐ฅ๐๐ญ๐๐ฌ๐ญ ๐๐ฅ๐ข๐ง๐ข๐๐จ๐ฉ๐๐ญ๐ก๐จ๐ฅ๐จ๐ ๐ข๐๐๐ฅ ๐ฎ๐ฉ๐๐๐ญ๐ ๐๐๐๐ซ๐๐ฌ๐ฌ๐ข๐ง๐ ๐ ๐ฉ๐๐ซ๐ฌ๐ข๐ฌ๐ญ๐๐ง๐ญ ๐ฉ๐๐ซ๐๐๐จ๐ฑ ๐ข๐ง ๐๐ฅ๐ณ๐ก๐๐ข๐ฆ๐๐ซ’๐ฌ ๐๐ข๐ฌ๐๐๐ฌ๐: ๐ฐ๐ก๐ฒ ๐ญ๐ก๐๐ซ๐๐ฉ๐ข๐๐ฌ ๐ญ๐๐ซ๐ ๐๐ญ๐ข๐ง๐ ๐ญ๐ก๐ ๐ซ๐๐ฆ๐จ๐ฏ๐๐ฅ ๐จ๐ ๐๐ฆ๐ฒ๐ฅ๐จ๐ข๐-ฮฒ ๐ฉ๐ฅ๐๐ช๐ฎ๐๐ฌ ๐๐ง๐ ๐ญ๐๐ฎ ๐ญ๐๐ง๐ ๐ฅ๐๐ฌ ๐๐จ๐ง๐ฌ๐ข๐ฌ๐ญ๐๐ง๐ญ๐ฅ๐ฒ ๐ฌ๐ก๐จ๐ฐ ๐ ๐๐ซ๐ข๐ญ๐ข๐๐๐ฅ ๐๐ข๐ฌ๐ฌ๐จ๐๐ข๐๐ญ๐ข๐จ๐ง ๐๐ซ๐จ๐ฆ ๐๐จ๐ซ๐ ๐๐ฅ๐ข๐ง๐ข๐๐๐ฅ ๐ฉ๐๐ญ๐ก๐จ๐ ๐๐ง๐๐ฌ๐ข๐ฌ. ๐๐ง “๐๐ฅ๐ณ๐ก๐๐ข๐ฆ๐๐ซ’๐ฌ ๐๐ข๐ฌ๐๐๐ฌ๐ ๐ข๐ง ๐ญ๐ก๐ ๐๐ฅ๐๐ฌ๐ญ๐ข๐๐๐ง๐ ๐๐ซ๐: ๐ ๐๐ฅ๐ข๐ง๐ข๐๐จ๐ฉ๐๐ญ๐ก๐จ๐ฅ๐จ๐ ๐ข๐๐๐ฅ ๐ฎ๐ฉ๐๐๐ญ๐ ๐จ๐ง ๐ญ๐ก๐ […]
Posted in About, Neuroplasticity, Pharma and Medical Device, Regulatory Medical Writing Comments Off on Alzheimer’s Dual Sequestration HypothesisDiffuse Lewy Body Dementia in the Great Robin Williams
Posted by Michael A. S. Guth on June 13th, 2026
I have the deepest, most profound respect for Robin Williams. I wish it were more widely known, while he was still living, what a decent, caring, sympathetic person Robin Williams was. I just finished watching the documentary โRobinโs Wishโ (available to stream on Plex and Tubi) and learned that the cause of death in the […]