1. Mechanisms of Stem Cell Exhaustion Telomere Attrition and Replicative Senescence: Studies have shown that telomere shortening in stem cells limits their replicative capacity, leading to senescence or apoptosis. For example, hematopoietic stem cells (HSCs) with critically short telomeres exhibit reduced self-renewal and differentiation potential (Ju et al., Cell Stem Cell, 2007). Telomerase activation has been […]

Dysbiosis, the imbalance in the composition and function of the gut microbiota, is increasingly recognized as a hallmark of aging due to its profound impact on systemic health and its role in age-related diseases. Here’s a detailed explanation of how dysbiosis contributes to aging: Mechanisms Linking Dysbiosis to Aging: Altered Microbial Composition: Reduced Diversity: Aging is […]

Stem cell exhaustion is recognized as a hallmark of aging due to its critical role in impairing tissue regeneration and homeostasis. Here’s a structured explanation of the mechanisms and implications: Key Mechanisms Leading to Stem Cell Exhaustion: Intrinsic Factors: Telomere Attrition: Stem cells have a finite replicative capacity (Hayflick limit). Telomere shortening with each division eventually […]